The Clomid vs. Enclomiphene Debate: SERM Stereospecificity & HPTA Recovery

I've tried both and

📌 Key Takeaways & Executive Summary

• Isomer Stereospecificity: Clomid (clomiphene citrate) is a racemic mixture of ~38% Zuclomiphene (pro-estrogenic, long half-life) and ~62% Enclomiphene (anti-estrogenic, rapid clearance).
• HPTA Axis Stimulation: Enclomiphene selectively blocks hypothalamic estrogen feedback, significantly increasing LH and FSH secretion to drive endogenous testosterone production.
• IGF-1 Preservation: Unlike Clomid which suppresses systemic IGF-1 levels due to hepatic zuclomiphene accumulation, pure Enclomiphene preserves circulating growth factor signaling.
• Clinical Indications: Preferred therapeutic modality for secondary hypogonadism and post-cycle HPTA restoration over legacy racemic SERMs.